abstract：PURPOSE:Caffeine is a non-selective antagonist of A1 and A2A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on A1R...

journal_title：Epilepsy research

authors： Esmaili Z,Heydari A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To evaluate if the duration of epilepsy influences MRI volumes of the hippocampus, amygdala, parahippocampal gyrus, entorhinal cortex and temporal pole of both hemispheres and epileptogenic hippocampus neuronal cell density and dentate gyrus granular cells distribution in patients with refractory mesial tempora...

journal_title：Epilepsy research

authors： Duarte JTC,Jardim AP,Comper SM,De Marchi LR,Gaça LB,Garcia MTFC,Sandim GB,Assunção-Leme IB,Carrete H Jr,Centeno RS,Lancellotti CLP,Jackowski AP,Cavalheiro EA,Guaranha MSB,Yacubian EMT

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:In many parts of eastern Asia, rice is a dietary staple and therefore the ketogenic diet (KD) can be difficult to administer. The aim of this study was to assess the long-term effectiveness and tolerability of the classical KD using a 2:1 ratio of fat to protein plus net carbohydrates, which is lower than th...

journal_title：Epilepsy research

authors： Lee HF,Chi CS,Liao JH

更新日期：2018-11-01 00:00:00

abstract：:The rat lateral fluid-percussion injury (FPI) model has been used extensively to study post-traumatic epilepsy (PTE). Epidemiological studies have reported that the risk of PTE is higher after more severe injury. Adult, male Wistar rats subjected to different atmospheric pressures of injury during FPI showed great var...

journal_title：Epilepsy research

authors： Smith D,Rau T,Poulsen A,MacWilliams Z,Patterson D,Kelly W,Poulsen D

更新日期：2018-11-01 00:00:00

abstract：:Surgical resection of the seizure onset zone (SOZ) requires that this region of the cortex is accurately localized. The onset of a seizure may be marked by transient discharges, but it also may be accompanied by oscillatory, sinusoidal electrographic activity, such as the EEG theta rhythm. However, because of the supe...

journal_title：Epilepsy research

authors： Kuo CC,Tucker DM,Luu P,Jenson K,Tsai JJ,Ojemann JG,Holmes MD

更新日期：2018-10-01 00:00:00

abstract：:Most people with epilepsy live in tropical countries. Perinatal factors seem to play a significant role in the occurrence of epilepsy. Available data provide different and sometimes contradictory conclusions on the role and the burden of these factors. The aim of our study was to evaluate the effect of these perinatal...

journal_title：Epilepsy research

authors： Dassi Tchoupa Revegue MH,Marin B,Ibinga E,Boumediene F,Preux PM,Ngoungou EB

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Acetaminophen is one of the most commonly used analgesic and antipyretic drugs. It has been reported that acetaminophen has anticonvulsant effects in several animal models of seizure. An active metabolite of acetaminophen, AM404, inhibits the uptake of the endocannabinoid anandamide. However, the mechanism of...

journal_title：Epilepsy research

authors： Suemaru K,Yoshikawa M,Aso H,Watanabe M

更新日期：2018-09-01 00:00:00

abstract：:Absence seizures are thought to be linked to abnormal interplays between regions of a thalamocortical network. However, the complexity of this widespread network makes characterizing the functional interactions among various brain regions challenging. Using whole-brain functional connectivity and network analysis of m...

journal_title：Epilepsy research

authors： Youssofzadeh V,Agler W,Tenney JR,Kadis DS

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Epilepsy is a diverse neurological condition with extreme genetic and phenotypic heterogeneity. The introduction of next-generation sequencing into the clinical laboratory has made it possible to investigate hundreds of associated genes simultaneously for a patient, even in the absence of a clearly defined synd...

journal_title：Epilepsy research

authors： Hesse AN,Bevilacqua J,Shankar K,Reddi HV

更新日期：2018-08-01 00:00:00

abstract：:Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a newly defined clinicoradiologic syndrome characterized by biphasic seizures and altered consciousness followed by restricted diffusion in the white matter on magnetic resonance imaging in acute phase. Intractable epilepsy commonly occur...

journal_title：Epilepsy research

authors： Ichimiya Y,Kaku N,Sanefuji M,Torio M,Mizuguchi S,Motomura Y,Muraoka M,Lee S,Baba H,Sonoda Y,Ishizaki Y,Sasazuki M,Sakai Y,Maehara Y,Ohga S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of the key factors in the progression of the disease. So, the neuroprotective role of dimethyl fumarate (DMF), a Nrf2 pathway activato...

journal_title：Epilepsy research

authors： Singh N,Vijayanti S,Saha L,Bhatia A,Banerjee D,Chakrabarti A

更新日期：2018-07-01 00:00:00

abstract：:Evidence shows neurosteroids play a key role in regulating epileptogenesis. Neurosteroids such as testosterone modulate seizure susceptibility through its transformation to metabolites which show proconvulsant and anticonvulsant effects, respectively. Reduction of testosterone by aromatase generates proconvulsant 17-β...

journal_title：Epilepsy research

authors： Iqbal R,Jain GK,Siraj F,Vohora D

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To study potential delays in epilepsy surgery in children with drug-resistant epilepsy (DRE) of early-onset. METHODS:Medical records were reviewed from 87 children with DRE and seizure onset before age 3 years who underwent epilepsy surgery between 2006 and 2015. Information was obtained about each child's e...

journal_title：Epilepsy research

authors： Prideaux L,Barton S,Maixner W,Harvey AS

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:Cryosurgery is an alternative technique for minimally invasive treatment of lesions. We have recently examined cryosurgery for epilepsy in animal models, and found that penicillin G (PG)-induced epileptiform discharges (EDs) mostly vanished after freezing. However, EDs were provoked again after insufficient ...

journal_title：Epilepsy research

authors： Tokiwa T,Zimin L,Inoue T,Nomura S,Suzuki M,Yamakawa T

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:Our objective was to propose a new on demand non-human primate model of mesial temporal lobe seizures suitable for pre-clinical innovative therapeutic research. METHODS:Five macaques were stereotaxically implanted unilaterally with a deep recording electrode in the hippocampus. For each experiment, penicillin ...

journal_title：Epilepsy research

authors： Sherdil A,Chabardès S,Guillemain I,Michallat S,Prabhu S,Pernet-Gallay K,David O,Piallat B

更新日期：2018-05-01 00:00:00

abstract：:Pharmacoresistant mesial temporal lobe epilepsy (mTLE) represents the major indication for epilepsy surgery. Since epilepsy surgery is an elective treatment option, preserving cognition is a high priority. Given the essential role of temporomesial structures in declarative long-term memory formation, surgical treatmen...

journal_title：Epilepsy research

authors： Witt JA,Hoppe C,Helmstaedter C

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:We performed targeted gene-panel sequencing for children with developmental and epileptic encephalopathy (DEE) and evaluated the clinical implications of genotype-phenotype correlations. METHODS:We assessed 278 children with DEE using a customized gene panel that included 172 genes, and extensively reviewed ...

journal_title：Epilepsy research

authors： Ko A,Youn SE,Kim SH,Lee JS,Kim S,Choi JR,Kim HD,Lee ST,Kang HC

更新日期：2018-03-01 00:00:00

abstract：:This study aimed to assess neuropsychiatric comorbidities and analyze risk factors in Chinese children with epilepsy. Children with epilepsy aged between 6 and 16 years from the Children's Hospital of Fudan University were included. Children with asthma and typically developing children were matched for age and gender...

journal_title：Epilepsy research

authors： Li T,Zhou H,Li Y,Li C,Zhang Y,Zhou Y,Wang Y

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Ictal activity itself can cause pathological cerebrospinal fluid (CSF) findings. However, data regarding pathological CSF findings caused by SE itself to date remain scarce. We here evaluated the frequency and specificity of pathological CSF findings in non-infectious SE. METHODS:We performed a retrospective...

journal_title：Epilepsy research

authors： Malter MP,Choi S,Fink GR

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:We studied the effect of fosphenytoin (FOS) pre-medication on the incidence and thresholds of after-discharges (ADs), seizures, and functional responses during electrical stimulation mapping (ESM). METHODS:As individualized by the attending epileptologist, FOS was given intravenously at 2 mg-phenytoin-equivale...

journal_title：Epilepsy research

authors： Arya R,Aungaroon G,Zea Vera A,Horn PS,Byars AW,Greiner HM,Mangano FT,Holland KD

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Large administrative databases may prove useful to assess epilepsy-related comorbidity and mortality. Despite their increased use, their validity as data source in epilepsy is yet under-ascertained. METHODS:Achmea is a large Dutch health insurance company covering about 25% of the population. We performed a...

journal_title：Epilepsy research

authors： Wassenaar M,Carpay JA,Sander JW,Thijs RD

更新日期：2018-01-01 00:00:00

abstract：:Seizure forecasting would improve the quality of life of patients with refractory epilepsy. Although early findings were optimistic, no single feature has been found capable of individually characterizing brain dynamics during transition to seizure. Cross-frequency phase amplitude coupling has been recently proposed a...

journal_title：Epilepsy research

authors： Gagliano L,Bou Assi E,Nguyen DK,Rihana S,Sawan M

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The NTRK2 gene encodes a member of the neurotrophic tyrosine kinase receptor family known as TrkB. It is a membrane-associated receptor with signaling and cellular differentiation properties that has been involved in neuropsychiatric disorders, including epilepsy. We report here the frequencies of NTRK2 allel...

journal_title：Epilepsy research

authors： Torres CM,Siebert M,Bock H,Mota SM,Krammer BR,Duarte JÁ,Bragatti JA,Castan JU,de Castro LA,Saraiva-Pereira ML,Bianchin MM

更新日期：2017-11-01 00:00:00

abstract：:Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [18F]fluorodeo...

journal_title：Epilepsy research

authors： Joutsa J,Rinne JO,Karrasch M,Hermann B,Johansson J,Anttinen A,Eskola O,Helin S,Shinnar S,Sillanpää M,TACOE study group.

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS:Eighty chi...

journal_title：Epilepsy research

authors： Isler C,Kucukyuruk B,Ozkara C,Gunduz A,Is M,Tanriverdi T,Comunoglu N,Oz B,Uzan M

更新日期：2017-10-01 00:00:00

abstract：:In this preliminary study, we evaluated the predictive ability of Correlation Dimension (CD) and Nonlinear Interdependence (NI) for seizures in pediatric myoclonic epilepsy patients. Scalp EEG recordings of eight diagnosed cases of myoclonic epilepsy were analyzed using Receiver Operating Curve (ROC) for discriminatin...

journal_title：Epilepsy research

authors： Kolarijani MAS,Amirsalari S,Haidari MR

更新日期：2017-09-01 00:00:00

abstract：:It has been established that febrile seizures and its extended syndromes like generalized epilepsy with febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes. In patients, the onset of FS is likely due to the combined effect of temperature and i...

journal_title：Epilepsy research

authors： Warner TA,Liu Z,Macdonald RL,Kang JQ

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Perampanel, a selective, noncompetitive AMPA receptor antagonist, is indicated as adjunctive therapy for the treatment of partial seizures with or without secondarily generalized seizures and primary generalized tonic-clonic seizures in patients with epilepsy aged 12years and older. In vitro studies and Phas...

journal_title：Epilepsy research

authors： Gidal BE,Maganti R,Laurenza A,Yang H,Verbel DA,Schuck E,Ferry J

更新日期：2017-08-01 00:00:00

abstract：:Brain glucose transport is dependent on glucose transporter 1 (GLUT1), encoded by the solute carrier family 2 member 1 (SLC2A1) gene. Mutations in SLC2A1 cause GLUT1 deficiency which is characterized by a broad spectrum of neurological phenotypes including generalized epilepsy, motor disorders, developmental delay and...

journal_title：Epilepsy research

authors： Peeraer A,Damiano JA,Bellows ST,Scheffer IE,Berkovic SF,Mullen SA,Hildebrand MS

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate whether there may be a correlation between the anatomical variants of Circle of Willis (CoW) and presence/laterality of mesial temporal sclerosis (MTS). METHODS:We retrospectively identified the CoW variants on Wada angiograms in 71 patients with pathologically proven...

journal_title：Epilepsy research

authors： Kuyumcu G,Byrne RW,Dawe RJ,Kocak M

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Epilepsy surgery is an effective treatment for refractory focal epilepsy. Risks of surgery need to be considered when advising individuals of treatment options. We describe the frequency and nature of physical adverse events associated with epilepsy surgery in a single center. MATERIAL AND METHODS:We revi...

journal_title：Epilepsy research

authors： Gooneratne IK,Mannan S,de Tisi J,Gonzalez JC,McEvoy AW,Miserocchi A,Diehl B,Wehner T,Bell GS,Sander JW,Duncan JS

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Despite increasing amounts of research on periodic discharges (PDs), large clinical studies regarding their prognostic value are lacking. The aim of the current study was to evaluate the clinical implications and prognostic value of PDs. METHODS:In this single-center retrospective cohort study, we included p...

journal_title：Epilepsy research

authors： Li HT,Wu T,Lin WR,Tseng WJ,Chang CW,Cheng MY,Hsieh HY,Chiang HI,Lee CH,Chang BL,Lim SN

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested that the early introduction of a ketogenic diet (KD) could improve seizure control in myoclono-astatic epilepsy (MAE). This multicenter study sought to identify the benefits of KD use on seizure control and epilepsy and on developmental outcomes in children with resistant MAE. M...

journal_title：Epilepsy research

authors： Stenger E,Schaeffer M,Cances C,Motte J,Auvin S,Ville D,Maurey H,Nabbout R,de Saint-Martin A

更新日期：2017-03-01 00:00:00

abstract：:Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects of an alcohol extrac...

journal_title：Epilepsy research

authors： Addae JI,Pingal R,Walkins K,Cruickshank R,Youssef FF,Nayak SB

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:There is shortage of specialists for the diagnosis of children with epilepsy, especially in resource limited settings. Existing INCLEN (International Clinical Epidemiology Network) instrument was validated for children aged 2-9 years. The current study validated modifications of the same including wider symp...

journal_title：Epilepsy research

authors： Gulati S,Patel H,Chakrabarty B,Dubey R,Arora NK,Pandey RM,Paul VK,Ramesh K,Anand V,Meena A

更新日期：2017-02-01 00:00:00

abstract：:Metalloproteinase 9 (MMP9) is a member of a family of enzymes that mediate the degradation of extracellular matrix proteins, and is especially involved in blood-brain barrier maintenance. Increased levels of MMP9 have been observed in many neurological disorders, including epilepsy, suggesting it may be involved in th...

journal_title：Epilepsy research

authors： Cudna A,Jopowicz A,Mierzejewski P,Kurkowska-Jastrzębska I

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:to determine the feasibility as well as the attitudes among caregivers of children and adolescents with epilepsy in China towards the use of smart phone applications (apps) for the management of seizures. METHODS:The caregivers of children and adolescents with epilepsy, ages ranging from 0 to 15 years, were ...

journal_title：Epilepsy research

authors： Liu X,Wang R,Zhou D,Hong Z

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Cases of temporal lobe epilepsy (TLE) with ipsilateral amygdala enlargement (AE) have increasingly been reported. However, the white matter (WM) abnormalities of TLE patients with AE remain poorly investigated. Here we explored macrostructural and microstructural WM abnormalities in TLE patients with AE compare...

journal_title：Epilepsy research

authors： Sone D,Ota M,Maikusa N,Kimura Y,Sumida K,Yokoyama K,Imabayashi E,Watanabe M,Watanabe Y,Okazaki M,Sato N,Matsuda H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critic...

journal_title：Epilepsy research

authors： Yuan Y,Xiang W,Yanhui L,Ruofei L,Yunhe M,Jiewen L,Qing M

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:To characterize, in adolescents aged 12-17, the pharmacokinetic (PK) profile of perampanel, the impact of intrinsic and extrinsic factors on PK, and the relationships between perampanel exposure and cognitive function, seizure frequency, and responder status. METHODS:Population PK analysis used plasma concen...

journal_title：Epilepsy research

authors： Villanueva V,Majid O,Nabangchang C,Yang H,Laurenza A,Ferry J,Hussein Z

更新日期：2016-11-01 00:00:00